Drosophila melanogasterGenAge entry for Thor (Drosophila melanogaster)

Gene information (ID: 880)

Symbol
Thor
Aliases
153432_at; 43-BP; 4e-bp; 4E-BP; 4E-BP1; 4ebp; 4eBP; 4EBP;
Name
CG8846 gene product from transcript CG8846-RA
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Null mutant flies show a diminished change in lifespan in response to dietary restriction, which can be rescued upon ubiquitously expression of wild-type Thor (d4E-BP). Overexpression of wild type 4E-BP caused no change in lifespan of males or females on rich food, while overexpression of a weak activated allele extended mean lifespan of females 14% (no significant extension in male flies). Induction of a strong allele extended male lifespan 11% and female lifespan 22% on rich food. Under dietary restriction, there was no additional lifespan extension.
% change in avg or median lifespan
Lifespan is up to 22% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Lifespan of flies with increased Pten and 4E-BP activity in muscles is extended in comparison with matched controls.
    % change in max lifespan
    Maximum lifespan is 15.8% higher.
    % change in avg or median lifespan
    Median lifespan is 20% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenDR gene manipulations
      • This gene is present as Thor

      Homologs in other organisms

      Danio rerio
      eif4ebp3
      Homo sapiens
      EIF4EBP3
      Mus musculus
      Eif4ebp3
      Rattus norvegicus
      Eif4ebp3

      External links

      FlyBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (33569)
      Homologues
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      UniProt
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      Internet
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