Saccharomyces cerevisiaeGenAge entry for TPO1 (Saccharomyces cerevisiae)

Gene information (ID: 1676)

Symbol
TPO1
Name
Transporter of POlyamines
Organism
Saccharomyces cerevisiae (AnAge)

Potential relevance to longevity and/or ageing

Observations
Deletion caused mean replicative lifespan decrease by 8.2% in the alpha strain and by 31.5% in the a strain
% change in avg or median lifespan
Replicative lifespan is 8-32% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Deletion
Longevity Category
Necessary for fitness
Primary reference
    Observations
    Overexpression caused replicative lifespan increase by 24.4% in the alpha strain and by 21.4% in the a strain
    % change in avg or median lifespan
    Replicative lifespan is 21-25% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference

      Homologs in other organisms

      Schizosaccharomyces pombe
      SPBC530.15c

      External links

      Saccharomyces Genome Database
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (850631)
      Homologues
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      UniProt
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      Internet
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