Saccharomyces cerevisiaeGenAge entry for TIF1 (Saccharomyces cerevisiae)

Gene information (ID: 1383)

Symbol
TIF1
Name
Translation Initiation Factor
Organism
Saccharomyces cerevisiae (AnAge)

Potential relevance to longevity and/or ageing

Observations
Replicative lifespan increased by 30% in the alpha strain and 15% in the a strain
% change in avg or median lifespan
Replicative lifespan is 15-30% higher.
Lifespan Effect
Increase
Genetic Manipulation
Deletion
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Replicative lifespan increased by 20% in the alpha strain
    % change in avg or median lifespan
    Replicative lifespan is 20% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Deletion
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      Mean chronological lifespan decreased in the a strain by less than 50% but more than 15%
      % change in avg or median lifespan
      Mean chronological lifespan is 15%-50% lower.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      Deletion
      Longevity Category
      Necessary for fitness
      Primary reference

        In other databases

        GenAge model organism genes
        • A homolog of this gene for Caenorhabditis elegans is present as inf-1

        Homologs in other organisms

        Caenorhabditis elegans
        inf-1
        Danio rerio
        eif4a2
        Drosophila melanogaster
        eIF-4a
        Homo sapiens
        EIF4A2
        Mus musculus
        Eif4a2
        Rattus norvegicus
        Eif4a2
        Schizosaccharomyces pombe
        tif1

        External links

        Saccharomyces Genome Database
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (853933)
        Homologues
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        UniProt
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        Internet
        Search Google or Search Google Scholar