Drosophila melanogasterGenAge entry for Su(var)205 (Drosophila melanogaster)

Gene information (ID: 1816)

Symbol
Su(var)205
Aliases
CBX5; CG8409; dHP-1a; dHP1; Dmel\CG8409; DmHP-1; DmHP1; E
Name
Suppressor of variegation 205
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Reducing HP1 levels by half, as in Su(var)2055 heterozygotes, caused a dramatic shortening of life span compared to isogenic controls (p = 2.03-86). Similar results were found with a second allele, Su(var)2052.
% change in max lifespan
Maximum lifespan is 55% lower.
% change in avg or median lifespan
Average lifespan is 60% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference
    Observations
    A moderate overexpression of HP1, caused by basal activity of the hsp70 promoter, significantly extended life span, resulting in a 23% increase in median life span and a 12% increase in maximum life span (p = 6.31-24).
    % change in max lifespan
    Maximum lifespan is 12% higher.
    % change in avg or median lifespan
    Median lifespan is 23% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference

      Homologs in other organisms

      Danio rerio
      cbx5

      External links

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