Drosophila melanogasterGenAge entry for Spargel (Drosophila melanogaster)

Gene information (ID: 1740)

Symbol
Spargel
Aliases
CG; 9809; cg9809; CG9809; Dmel\CG9809; dPGC; dPGC-1; PGC-
Name
Spargel
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Tissue-specific overexpression of dPGC-1 in stem and progenitor cells within the digestive tract of female flies extends lifespan. Flies display a delay in the onset of aging-related changes in the intestine, leading to improved tissue homeostasis in old flies.
% change in max lifespan
Maximum female lifespan is up to 37% higher.
% change in avg or median lifespan
Median female lifespan is up to 33% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression in stem and progenitor cells
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    pprc1
    Rattus norvegicus
    Ppargc1b

    External links

    FlyBase
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (40562)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar