Mus musculusGenAge entry for Socs2 (Mus musculus)

Gene information (ID: 826)

Symbol
Socs2
Aliases
hg; JAB; CIS2; Cish2; SSI-2; SOCS-2; AI527257; AW108012; 8
Name
Suppressor of cytokine signaling 2
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Mutant mice exhibited a reduced mean and maximal lifespan compared to wild type. The lack of SOCS2 expression in the high-growth mouse also increases plasma IGF1, and reduces plasma and pituitary GH levels.
% change in max lifespan
Maximum lifespan is 14% lower.
% change in avg or median lifespan
Average lifespan is 35% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutations
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    No homologs found

    External links

    Mouse Genome Informatics
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    Entrez Gene
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    Homologues
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    UniProt
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    Internet
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