Mus musculusGenAge entry for Sirt6 (Mus musculus)

Gene information (ID: 610)

Symbol
Sirt6
Aliases
Sir2l6; AI043036; 2810449N18Rik
Name
sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae)
Organism
Mus musculus (AnAge)
Known functions and activities
NAD(+)-dependent histone deacetylase that silences gene expression

Potential relevance to longevity and/or ageing

Observations
Overexpression of Sirt6 in mice increases lifespan by 10-14.5% in males, but not in females. Males also had lower levels of IGF1.
% change in max lifespan
Maximum lifespan is 14.5% higher.
% change in avg or median lifespan
Average lifespan is 12% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Knockout mice develop signs of premature ageing including a short lifespan.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Knockout
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Drosophila melanogaster is present as Sirt6
      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as SIRT6
      LongevityMap
      • A homolog of this gene for Homo sapiens is present as SIRT6
      CellAge
      • A homolog of this gene for Homo sapiens is present as SIRT6

      Homologs in other organisms

      Caenorhabditis elegans
      sir-2.4
      Danio rerio
      sirt6
      Drosophila melanogaster
      Sirt6
      Homo sapiens
      SIRT6
      Rattus norvegicus
      Sirt6

      External links

      Mouse Genome Informatics
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (50721)
      Homologues
      Search HomoloGene
      UniProt
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      Internet
      Search Google or Search Google Scholar