Drosophila melanogasterGenAge entry for Sirt6 (Drosophila melanogaster)

Gene information (ID: 611)

Symbol
Sirt6
Aliases
CG6284; D.mel4; Dmel\CG6284; dmSRT408; dSIRT6
Name
CG6284-PB
Organism
Drosophila melanogaster (AnAge)
Known functions and activities
NAD(+)-dependent histone deacetylase that silences gene expression

Potential relevance to longevity and/or ageing

Observations
Decreased expression by RNA interference caused lethality during development. Silencing in neurons shortened mean lifespan by 20%.
% change in avg or median lifespan
Average lifespan is 20% lower.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Mus musculus is present as Sirt6
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as SIRT6
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as SIRT6
    CellAge
    • A homolog of this gene for Homo sapiens is present as SIRT6

    Homologs in other organisms

    Caenorhabditis elegans
    sir-2.4
    Danio rerio
    sirt6
    Homo sapiens
    SIRT6
    Mus musculus
    Sirt6
    Rattus norvegicus
    Sirt6

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (41254)
    Homologues
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    UniProt
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    Internet
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