Drosophila melanogasterGenAge entry for Sirt2 (Drosophila melanogaster)

Gene information (ID: 609)

Symbol
Sirt2
Aliases
CG5085; D.mel2; Dmel\CG5085; dSIRT2; SIRT2
Name
CG5085-PA
Organism
Drosophila melanogaster (AnAge)
Known functions and activities
NAD(+)-dependent histone deacetylase that silences gene expression

Potential relevance to longevity and/or ageing

Observations
Decreased expression by RNA interference caused lethality during development. Silencing in neurons shortened mean lifespan by 20%.
% change in avg or median lifespan
Average lifespan is 20% lower.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as HST2
    GenDR gene manipulations
    • A homolog of this gene for Saccharomyces cerevisiae is present as HST2

    Homologs in other organisms

    Danio rerio
    sirt2
    Homo sapiens
    SIRT2
    Mus musculus
    Sirt2
    Rattus norvegicus
    Sirt2
    Saccharomyces cerevisiae
    HST2
    Schizosaccharomyces pombe
    hst2

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (42414)
    Homologues
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    UniProt
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    Internet
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