Mus musculusGenAge entry for Sirt1 (Mus musculus)

Gene information (ID: 1011)

Symbol
Sirt1
Aliases
Sir2; Sir2a; SIR2L1; AA673258; Sir2alpha
Name
Sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae)
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Moderate overexpression of Sirt1 improve healthy ageing but do not increase lifespan.
Lifespan Effect
Noeffect
Genetic Manipulation
Overexpression
Longevity Category
Not Recorded
Primary reference
    Observations
    Brain-specific Sirt1-overexpressing mice are long-lived. Females live 16% longer and males 9% longer than controls.
    % change in avg or median lifespan
    Average lifespan is 12.5% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      SIRT1 mutant mice were small, and exhibited notable developmental defects of the retina and heart, and only infrequently survived postnatally.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      Mutations
      Longevity Category
      Pro-Longevity
      Primary reference
        Observations
        Transgenic mice, overexpressing Sirt1, display some phenotypes similar to mice on a calorie-restricted diet: they are leaner than littermate controls; are more metabolically active; display reductions in blood cholesterol, adipokines, insulin and fasted glucose; and are more glucose tolerant. Furthermore, transgenic mice perform better on a rotarod challenge and also show a delay in reproduction.
        Lifespan Effect
        Increase
        Genetic Manipulation
        Overexpression
        Longevity Category
        Pro-Longevity
        Primary reference

          In other databases

          GenAge model organism genes
          • A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
          • A homolog of this gene for Drosophila melanogaster is present as Sir2
          GenAge human genes
          • A homolog of this gene for Homo sapiens is present as SIRT1
          GenDR gene manipulations
          • A homolog of this gene for Drosophila melanogaster is present as Sir2
          • This gene is present as Sirt1
          • A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
          LongevityMap
          • A homolog of this gene for Homo sapiens is present as SIRT1
          CellAge
          • A homolog of this gene for Homo sapiens is present as SIRT1

          Homologs in other organisms

          Caenorhabditis elegans
          sir-2.1
          Danio rerio
          sirt1
          Drosophila melanogaster
          Sir2
          Homo sapiens
          SIRT1
          Rattus norvegicus
          Sirt1

          External links

          Mouse Genome Informatics
          Search
          Ensembl
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          Entrez Gene
          View on Entrez Gene database (93759)
          Homologues
          Search HomoloGene
          UniProt
          Search
          Internet
          Search Google or Search Google Scholar