Mus musculusGenAge entry for Siglece (Mus musculus)

Gene information (ID: 2082)

Symbol
Siglece
Name
sialic acid binding Ig-like lectin E
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Siglece-/- mice exhibited reduced survival and showed accelerated ageing as a result of imbalanced ROS metabolism and impaired detoxication of reactive molecules, which lead to increased oxidative stress. Overall survival of Siglece-/- males was 48% compared to 70% for the wildtype. Median survival of Siglece-/- decreased by 17%.
% change in avg or median lifespan
Median lifespan is 17% lower in females.
Lifespan Effect
Decrease
Genetic Manipulation
Deletion
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Homo sapiens
    SIGLEC12
    Rattus norvegicus
    Siglec8

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (83382)
    Homologues
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    UniProt
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    Internet
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