Mus musculusGenAge entry for Serpine1 (Mus musculus)

Gene information (ID: 1851)

Symbol
Serpine1
Name
serine (or cysteine) peptidase inhibitor, clade E, member 1
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
The KLOTHO-deficient mice exhibit an accelerated aging phenotype including reduced lifespan, arteriosclerosis, and emphysema. PAI-1 (SERPINE1) deficiency retards the development of senescence and protects organ structure and function while prolonging the lifespan of the mutant mice. Median lifespan of KLOTHO/PAI-1 deficient mice is 2.8-fold and 4.2-fold higher (for PAI-1+/- and PAI-1-/- respectively) than the lifespan of KLOTHO deficient mice. Similar lifespan prolongation was obtained pharmacologically with a PAI-1 antagonist. Both males and females appear to benefit from complete PAI-1 deficiency, whil pai-1+/- deficiency had a smaller effect on females than on males. Maximum lifespan is also increased. The lifespan extension was also accompanied by increased overall vigor and health, the mutant mice exhibiting near-normal weight gain over time and spontaneous physical activity.
Lifespan Effect
Increase
Genetic Manipulation
Deletion in the Klotho mutant background
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    No homologs found

    External links

    Mouse Genome Informatics
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    Entrez Gene
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