Saccharomyces cerevisiaeGenAge entry for SIR2 (Saccharomyces cerevisiae)

Gene information (ID: 606)

Symbol
SIR2
Aliases
MAR1
Name
Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
Organism
Saccharomyces cerevisiae (AnAge)
Known functions and activities
NAD(+)-dependent histone deacetylase that silences gene expression

Potential relevance to longevity and/or ageing

Observations
Overexpression extended lifespan by about 30%.
% change in avg or median lifespan
Lifespan is about 30% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Lack of Sir2 along with calorie restriction and/or mutations in the yeast AKT homolog, Sch9, or Ras pathways causes a dramatic chronological LS extension (6 fold).
    % change in avg or median lifespan
    Chronological lifespan is up to 6 fold higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Deletion
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      Mean chronological lifespan increased in the a strain
      Lifespan Effect
      Increase
      Genetic Manipulation
      Deletion
      Longevity Category
      Anti-Longevity
      Primary reference

        In other databases

        GenDR gene manipulations
        • This gene is present as SIR2

        Homologs in other organisms

        Caenorhabditis elegans
        sir-2.4

        External links

        Saccharomyces Genome Database
        Search
        Ensembl
        Search
        Entrez Gene
        View on Entrez Gene database (851520)
        Homologues
        Search HomoloGene
        UniProt
        Search
        Internet
        Search Google or Search Google Scholar