Saccharomyces cerevisiaeGenAge entry for SIP2 (Saccharomyces cerevisiae)

Gene information (ID: 603)

Symbol
SIP2
Aliases
SPM2
Name
Sip2p
Organism
Saccharomyces cerevisiae (AnAge)
Known functions and activities
One of three beta subunits of the Snf1 serine/threonine protein kinase complex

Potential relevance to longevity and/or ageing

Observations
The esa1-531 strain showed a shortened replicative lifespan when grown at a semi-permissive temperature, 30C. Importantly, in an esa1-531 strain, the lysine-to-glutamine mutants of SIP2 (sip2-3KQ and sip2-4KQ), mimicking acetylated Sip2, reversed the shortened lifespan of esa1-531.
% change in avg or median lifespan
Median lifespan is 60% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Acetylation mutants
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Deletion results in reduced resistance to nutrient deprivation and a shorter lifespan accompanied by signs of accelerated ageing such as accumulation of extrachromosomal rDNA.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Deletion
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      Replicative lifespan increased by 20% in the alpha strain
      % change in avg or median lifespan
      Replicative lifespan is 20% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      Deletion
      Longevity Category
      Anti-Longevity
      Primary reference
        Observations
        Mean chronological lifespan increased in the a strain
        Lifespan Effect
        Increase
        Genetic Manipulation
        Deletion
        Longevity Category
        Anti-Longevity
        Primary reference

          Homologs in other organisms

          No homologs found

          External links

          Saccharomyces Genome Database
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          Ensembl
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          Entrez Gene
          View on Entrez Gene database (852664)
          Homologues
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          UniProt
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          Internet
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