Saccharomyces cerevisiaeGenAge entry for SGS1 (Saccharomyces cerevisiae)

Gene information (ID: 600)

Symbol
SGS1
Name
Sgs1p
Organism
Saccharomyces cerevisiae (AnAge)
Known functions and activities
Nucleolar DNA helicase of the RecQ family involved in maintenance of genome integrity

Potential relevance to longevity and/or ageing

Observations
Mutations cause premature ageing in mother cells including a shortened lifespan, sterility, and redistribution of the Sir3 silencing protein from telomeres to the nucleolus.
Lifespan Effect
Decrease
Genetic Manipulation
Mutations
Longevity Category
Necessary for fitness
Primary reference
    Observations
    Replicative lifespan decreased by 30%
    % change in avg or median lifespan
    Replicative lifespan is 30% lower.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Deletion
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      A shortened life span
      Lifespan Effect
      Decrease
      Genetic Manipulation
      Mutation
      Longevity Category
      Pro-Longevity
      Primary reference
        Observations
        To investigate the role of the RecQ helicase domain in ageing, a point mutation (SGS1 K(706)-->A) known to eliminate the DNA helicase activity of Sgs1p was constructed. This mutant allele failed to rescue the premature ageing of the sgs1Delta strain, demonstrating that Sgs1p DNA helicase activity is required for a normal lifespan
        Lifespan Effect
        Decrease
        Genetic Manipulation
        Mutation
        Longevity Category
        Pro-Longevity
        Primary reference

          In other databases

          GenAge human genes
          • A homolog of this gene for Homo sapiens is present as WRN
          LongevityMap
          • A homolog of this gene for Homo sapiens is present as WRN
          CellAge
          • A homolog of this gene for Homo sapiens is present as WRN

          Homologs in other organisms

          Caenorhabditis elegans
          wrn-1
          Drosophila melanogaster
          mus309
          Homo sapiens
          WRN
          Mus musculus
          Wrn
          Rattus norvegicus
          Blm
          Schizosaccharomyces pombe
          rqh1

          External links

          Saccharomyces Genome Database
          Search
          Ensembl
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          Entrez Gene
          View on Entrez Gene database (855228)
          Homologues
          Search HomoloGene
          UniProt
          Search
          Internet
          Search Google or Search Google Scholar