Saccharomyces cerevisiaeGenAge entry for SCH9 (Saccharomyces cerevisiae)

Gene information (ID: 590)

Symbol
SCH9
Aliases
HRM2; KOM1
Name
Protein kinase that regulates signal transduction activity and G1 progression
Organism
Saccharomyces cerevisiae (AnAge)
Known functions and activities
Controls cAPK activity, required for nitrogen activation of the FGM pathway

Potential relevance to longevity and/or ageing

Observations
Mutations increase resistance to oxidants and extend lifespan by up to threefold. Stress-resistance transcription factors Msn2/Msn4 and protein kinase Rim15 are required for this life-extension.
Lifespan Effect
Increase
Genetic Manipulation
Mutations
Longevity Category
Anti-Longevity
Primary reference
    Observations
    The deletion of SCH9, which encodes for a serine threonine kinase, triples the mean life span and increases resistance to oxidative and thermal stress. Mutations that decrease the activity of the Ras/Cyr1/PKA pathway also extend longevity and increase stress resistance by activating transcription factors Msn2/Msn4 and the mitochondrial antioxidant enzyme superoxide dismutase (Sod2).
    Lifespan Effect
    Increase
    Genetic Manipulation
    Deletion
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      More than 3 fold extension of chronological lifespan, by day 9 of medium depletion all the WT yeast were dead while 50% sch9 mutants survived
      % change in avg or median lifespan
      Chronological lifespan is more than 3 fold higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      Mutation
      Longevity Category
      Anti-Longevity
      Primary reference
        Observations
        Replicative lifespan increased by 40% in the alpha strain
        % change in avg or median lifespan
        Replicative lifespan is 40% higher.
        Lifespan Effect
        Increase
        Genetic Manipulation
        Deletion
        Longevity Category
        Anti-Longevity
        Primary reference

          In other databases

          GenDR gene manipulations
          • This gene is present as SCH9

          Homologs in other organisms

          Schizosaccharomyces pombe
          sck1

          External links

          Saccharomyces Genome Database
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          Ensembl
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          Entrez Gene
          View on Entrez Gene database (856612)
          Homologues
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          UniProt
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          Internet
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