Mus musculusGenAge entry for Rbm38 (Mus musculus)

Gene information (ID: 1978)

Symbol
Rbm38
Aliases
Seb4; Rnpc1; Seb4l
Name
RNA binding motif protein 38
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Rbm38-null mice exhibit signs of accelerated ageing and live shorter than wild-type. While during their first year of life, mutants are indistinguishable from wild type mice, by 18 month, most of the mutant mice exhibit weight loss (mostly due to smaller adipocytes), reduced ratio of gonadal fat vs. body weight, lordokyphosis (displaying a hunchback) and ulcerated skin lesions. They are also more prone to hematopoietic defects and spontaneous tumors. Median and maximum survival time for tumor-free mice was reduced compared to wild type mice by 22% and 11%, respectively.
% change in max lifespan
Maximum tumor-free survival is 11% lower.
% change in avg or median lifespan
Median tumor-free survival is 11% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Knockout
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Caenorhabditis elegans
    sup-12
    Homo sapiens
    RBM38
    Rattus norvegicus
    Rbm38

    External links

    Mouse Genome Informatics
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    Entrez Gene
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    Homologues
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    UniProt
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    Internet
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