Mus musculusGenAge entry for Pten (Mus musculus)

Gene information (ID: 1012)

Symbol
Pten
Aliases
TEP1; MMAC1; AI463227; 2310035O07Rik; A130070J02Rik; B4
Name
Phosphatase and tensin homolog
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Median survival for Pten+/- male and female mice was 417 and 289 days, respectively (compared with >650 days for wild type C57BL6 mice), with deaths due to early cancer development, mainly lymphomas. Survival of Pten+/- mice was reduced to <40% normal life span due to early tumor development. Inhibition of mTor kinase with rapamycin, a downstream effector of Akt, inhibits lymphomagenesis and extends the survival of Pten+/- mice.
Lifespan Effect
Decrease
Genetic Manipulation
Deletion
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Pten(tg) mice carrying additional genomic copies of Pten are protected from cancer and present a significant extension of life span that is independent of their lower cancer incidence. In addition, mutant mice displayed enchanced protection from insulin resistance and steatosis, an increased energy expenditure and a hyperactive brown adipose tissue.
    % change in max lifespan
    Maximum lifespan was up to 16% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Drosophila melanogaster is present as Pten
      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as PTEN

      Homologs in other organisms

      Caenorhabditis elegans
      tag-83
      Danio rerio
      ptena
      Drosophila melanogaster
      Pten
      Homo sapiens
      PTEN
      Rattus norvegicus
      Pten

      External links

      Mouse Genome Informatics
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (19211)
      Homologues
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      UniProt
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      Internet
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