Mus musculusGenAge entry for Prkar2b (Mus musculus)

Gene information (ID: 1738)

Symbol
Prkar2b
Aliases
Pkarb2; AI451071; AW061005; RII(beta); PKARIIbeta
Name
protein kinase, cAMP dependent regulatory, type II beta
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Both the median and maximum lifespan (defined as 80% mortality) were significantly increased in knockout males compared to WT littermates. Mutant mice maintained their lean phenotype into old age and showed modestly lower blood glucose. Male mutants were also resistant to age-induced fatty liver, had a decrease in tumor incidence, severity of renal lesions, and age-related cardiac pathology.
% change in avg or median lifespan
Median male lifespan is 14% higher.
Lifespan Effect
Increase
Genetic Manipulation
Knockout
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    Drosophila melanogaster
    Pka-R2
    Homo sapiens
    PRKAR2B
    Rattus norvegicus
    Prkar2b

    External links

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    Entrez Gene
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    Internet
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