Mus musculusGenAge entry for Pparg (Mus musculus)

Gene information (ID: 823)

Symbol
Pparg
Aliases
Nr1c3; PPARgamma; PPAR-gamma; PPARgamma2; PPAR-gamma2
Name
Peroxisome proliferator activated receptor gamma
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
On a chow diet, despite equal food intake, Ala/Ala knock-in mice display beneficial changes in fat mass, circulating lipids, and insulin sensitivity, compared to their Pro/Pro littermates. Ala/Ala mice also gained less weight than Pro/Pro mice both in fat and lean body mass, and their lifespan is average 13% longer.
% change in avg or median lifespan
Average lifespan is 13% higher.
Lifespan Effect
Increase
Genetic Manipulation
Knockin
Primary reference
    Observations
    Lowered expression of Pparg reduced lifespan in both the lipodystrophic Pparg1/2-hypomorphic and the Pparg2-deficient mice.
    % change in avg or median lifespan
    Median lifespan is approximately 11% lower.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Mutations
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as PPARG
      LongevityMap
      • A homolog of this gene for Homo sapiens is present as PPARG

      Homologs in other organisms

      Danio rerio
      pparg
      Homo sapiens
      PPARG
      Rattus norvegicus
      Pparg

      External links

      Mouse Genome Informatics
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (19016)
      Homologues
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      UniProt
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      Internet
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