Mus musculusGenAge entry for Polg (Mus musculus)

Gene information (ID: 512)

Symbol
Polg
Aliases
PolgA; AA409516
Name
Polymerase (DNA directed), gamma
Organism
Mus musculus (AnAge)
Known functions and activities
Involved in mitochondrial DNA replication and repair

Potential relevance to longevity and/or ageing

Observations
Mice with a proof-reading-deficient version of Polg display an increased amount of mtDNA mutations and signs of premature ageing including a reduced lifespan, weight loss, reduced subcutaneous fat, alopecia, kyphosis, osteoporosis, anaemia, reduced fertility, and heart enlargement.
Lifespan Effect
Decrease
Genetic Manipulation
Mutations
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Mice with a proofreading-deficient version of the mitochondrial DNA polymerase g (POLG) resulted in premature aging and cancer.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Mutations
    Longevity Category
    Pro-Longevity
    Primary reference

      Homologs in other organisms

      No homologs found

      External links

      Mouse Genome Informatics
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      Entrez Gene
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      Internet
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