Mus musculusGenAge entry for Plau (Mus musculus)

Gene information (ID: 509)

Symbol
Plau
Aliases
uPA; u-PA
Name
Plasminogen activator, urokinase
Organism
Mus musculus (AnAge)
Known functions and activities
A protease that converts plasminogen to plasmin

Potential relevance to longevity and/or ageing

Observations
Overexpression in the brain of transgenic mice resulted in less food consumption (20%), reduced body weight (20%), reduced temperature, and a prolonged lifespan (20%).
% change in avg or median lifespan
Lifespan is 20% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as PLAU

    Homologs in other organisms

    Danio rerio
    plaua
    Homo sapiens
    PLAU
    Rattus norvegicus
    Plau

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (18792)
    Homologues
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    UniProt
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    Internet
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