Drosophila melanogasterGenAge entry for Pink1 (Drosophila melanogaster)

Gene information (ID: 2010)

Symbol
Pink1
Name
PTEN-induced putative kinase 1
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Transgenic overexpression of Pink1 results in an increase in mean lifespan (18%) mean = 72 days) when compared to wild-type controls. This effect is enhanced even more (up to 41%) when alpha-synuclein is also overexpressed. In both cases, lifespan extension is accompanied by an increase in healthspan.
% change in avg or median lifespan
Mean lifespan is 18% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    pink1
    Mus musculus
    Pink1

    External links

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