Drosophila melanogasterGenAge entry for Pi3K92E (Drosophila melanogaster)

Gene information (ID: 874)

Symbol
Pi3K92E
Aliases
anon-92Ed; CG4141; Dmel\CG4141; Dmp110; dp110; dP110; Dp
Name
CG4141 gene product from transcript CG4141-RA
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Overexpression of a dominant-negative PI3Kinase (DP110) resulted in mutants that have impaired regeneration of the intestinal epithelium and are short lived.
% change in avg or median lifespan
Average male lifespan is 2.8% lower; Average female lifespan is 5.0% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Knock-down
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as age-1
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as PIK3CB
    GenDR gene manipulations
    • A homolog of this gene for Caenorhabditis elegans is present as age-1
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as PIK3CB

    Homologs in other organisms

    Caenorhabditis elegans
    age-1
    Danio rerio
    pik3cb
    Homo sapiens
    PIK3CB
    Mus musculus
    Pik3cb
    Rattus norvegicus
    Pik3cd

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (42446)
    Homologues
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    UniProt
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    Internet
    Search Google or Search Google Scholar