Mus musculusGenAge entry for Parp1 (Mus musculus)

Gene information (ID: 1010)

Symbol
Parp1
Aliases
PARP; PPOL; ARTD1; Adprp; Adprt1; C80510; parp-1; sPARP-1
Name
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
hPARP-1 mice exhibit impaired survival rates accompanied by reduced hair growth and premature development of several inflammation and age-associated pathologies, such as adiposity, kyphosis, nephropathy, dermatitis, pneumonitis, cardiomyopathy, hepatitis, and anemia. Mutant male mice showed impaired glucose tolerance, however without developing manifest diabetes. 25% reduction in mean lifespan was observed. No difference in maximal lifespan compared to wt was observed.
% change in avg or median lifespan
Average lifespan is 25% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    No homologs found

    External links

    Mouse Genome Informatics
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    Entrez Gene
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    Internet
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