Saccharomyces cerevisiaeGenAge entry for PNC1 (Saccharomyces cerevisiae)

Gene information (ID: 1015)

Symbol
PNC1
Name
Pyrazinamidase and NiCotinamidase
Organism
Saccharomyces cerevisiae (AnAge)

Potential relevance to longevity and/or ageing

Observations
Increased expression of PNC1 is both necessary and sufficient for replicative lifespan extension by calorie restriction and low-intensity stress. under non-stressing conditions (2% glucose, 30C), a strain with additional copies of PNC1 (5XPNC1) had 70% longer replicative lifespan than the wild type and some cells lived for more than 70 divisions.Neither calorie restriction nor heat stress further increased the lifespan of the 5XPNC1 strain.
% change in avg or median lifespan
Replicative lifespan is 70% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    PNC1 overexpression suppresses the inhibitory effect of exogenously added NAM on silencing, life span, and Hst1-mediated transcriptional repression.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      Chronological lifespan decreased
      Lifespan Effect
      Decrease
      Genetic Manipulation
      Deletion
      Longevity Category
      Pro-Longevity
      Primary reference

        In other databases

        GenAge model organism genes
        • A homolog of this gene for Drosophila melanogaster is present as Naam
        GenDR gene manipulations
        • This gene is present as PNC1

        Homologs in other organisms

        Caenorhabditis elegans
        pnc-2
        Drosophila melanogaster
        Naam
        Schizosaccharomyces pombe
        pnc1

        External links

        Saccharomyces Genome Database
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (852846)
        Homologues
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        UniProt
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        Internet
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