Mus musculusGenAge entry for Nfkb1 (Mus musculus)

Gene information (ID: 1956)

Symbol
Nfkb1
Name
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Both mean and maximum lifespan are reduced in nfkb1-/- mice. The reduction in lifespan is also acompanied by multiple signs of premature ageing (hair loss or early greying, scruffy fur and cachexia, skin inflammation and delayed wound healing, thinning of the epidermis, lost neuromuscular coordination, premature body mass loss and loss of fat from inguinal, epididymal and mesenteric depots).
% change in avg or median lifespan
Median lifespan is approximately 33% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Knockout
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as NFKB1
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as NFKB1

    Homologs in other organisms

    Homo sapiens
    NFKB1
    Rattus norvegicus
    Nfkb1

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (18033)
    Homologues
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    UniProt
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    Internet
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