Drosophila melanogasterGenAge entry for Nf1 (Drosophila melanogaster)

Gene information (ID: 459)

Symbol
Nf1
Aliases
CG8318; Dmel\CG8318; dNF1; Nf-1; NF-1; nf1; NF1
Name
Neurofibromin 1
Organism
Drosophila melanogaster (AnAge)
Known functions and activities
Tumor supressor

Potential relevance to longevity and/or ageing

Observations
NF1 mutants had a shortened lifespan and exhibited increased vulnerability to heat and oxidative stress as well as reduced mitochondrial respiration and elevated ROS production. Overexpression of NF1 increased mitochondrial respiration and reduced ROS production. It increased mean lifespan by 49% in males and 68% in females and maximum lifespan by 38% in males and 52% in females. It also improved reproductive fitness.
% change in max lifespan
Maximum male lifespan is 38% higher; Maximum female lifespan is 52% higher.
% change in avg or median lifespan
Average male lifespan is 49% higher; Average female lifespan is 69% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    nf1b
    Homo sapiens
    NF1
    Mus musculus
    Nf1
    Rattus norvegicus
    Nf1

    External links

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    Entrez Gene
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    Homologues
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    Internet
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