Mus musculusGenAge entry for Neil1 (Mus musculus)

Gene information (ID: 458)

Symbol
Neil1
Aliases
Nei1; 2810450N13Rik
Name
nei endonuclease VIII-like 1 (E. coli)
Organism
Mus musculus (AnAge)
Known functions and activities
Base excision repair of ring-fragmented purines and some saturated pyrimidines

Potential relevance to longevity and/or ageing

Observations
Knockout mice develop severe obesity, dyslipidemia, fatty liver disease, increased levels of DNA damage in the mtDNA, and have a tendency to develop hyperinsulinemia.
Lifespan Effect
Decrease
Genetic Manipulation
Knockout
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    neil1
    Homo sapiens
    NEIL1
    Rattus norvegicus
    Neil1

    External links

    Mouse Genome Informatics
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (72774)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar