Saccharomyces cerevisiaeGenAge entry for NPT1 (Saccharomyces cerevisiae)

Gene information (ID: 470)

Symbol
NPT1
Name
Nicotinatephosphoribosyltranfserase
Organism
Saccharomyces cerevisiae (AnAge)
Known functions and activities
Critical for the NAD+ salvage pathway

Potential relevance to longevity and/or ageing

Observations
Increased dosage increases sir2-dependent silencing and extends yeast replicative lifespan by up to 60%.
% change in avg or median lifespan
Replicative lifespan is up to 60% higher.
Lifespan Effect
Increase
Genetic Manipulation
Increased dosage
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Chronological lifespan decreased
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Deletion
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      Replicative lifespan decreased by 50%
      % change in avg or median lifespan
      Replicative lifespan is 50% lower.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      Deletion
      Longevity Category
      Necessary for fitness
      Primary reference

        In other databases

        GenDR gene manipulations
        • This gene is present as NPT1

        Homologs in other organisms

        Caenorhabditis elegans
        Y54G2A.17
        Danio rerio
        naprt1
        Drosophila melanogaster
        CG3714
        Schizosaccharomyces pombe
        SPAC1486.06

        External links

        Saccharomyces Genome Database
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (854384)
        Homologues
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        UniProt
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        Internet
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