Mus musculusGenAge entry for Mtbp (Mus musculus)

Gene information (ID: 2144)

Symbol
Mtbp
Name
Mdm2, transformed 3T3 cell double minute p53 binding protein
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Mtbp is a positive regulator of Myc. Both male and female Mtbp+/? mice showed a 20% increase in median lifespan when compared to wild type mice. Mtbp+/? also showed increased maximal lifespan. Mtbp deletion had no effect on movement, production or development but did have increased metabolism and delayed tumour development.
% change in avg or median lifespan
Median lifespan is 20% higher.
Lifespan Effect
Increase
Genetic Manipulation
Deletion
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    LOC100534898
    Homo sapiens
    MTBP
    Rattus norvegicus
    Mtbp

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (105837)
    Homologues
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    UniProt
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    Internet
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