Mus musculusGenAge entry for Msh2 (Mus musculus)

Gene information (ID: 444)

Symbol
Msh2
Aliases
AI788990
Name
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
Organism
Mus musculus (AnAge)
Known functions and activities
DNA mismach repair

Potential relevance to longevity and/or ageing

Observations
About 50% of knock-out animals were dead by 8 month of age and all animals were dead by 12 month of age because of increased incidence of multiple cancers making these model as putatively progeroid.
Lifespan Effect
Decrease
Genetic Manipulation
Knockout
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as MSH2
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as MSH2

    Homologs in other organisms

    Caenorhabditis elegans
    msh-2
    Danio rerio
    msh2
    Drosophila melanogaster
    spel1
    Homo sapiens
    MSH2
    Rattus norvegicus
    Msh2
    Saccharomyces cerevisiae
    MSH2
    Schizosaccharomyces pombe
    msh2

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (17685)
    Homologues
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    UniProt
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    Internet
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