Drosophila melanogasterGenAge entry for Mrp4 (Drosophila melanogaster)

Gene information (ID: 1874)

Symbol
Mrp4
Name
Multidrug resistance protein 4 ortholog
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Compared to wild-type controls, dMRP4 mutant flies have a much shorter mean lifespan (by about 47%) and a decreased in maximum lifespan (by 24%).
% change in max lifespan
Maximum lifespan is 24% lower.
% change in avg or median lifespan
Mean lifespan is 47% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Flies overexpressing dMRP4 have an increased mean lifespan of up to 16% and an increased maximum lifespan of up to 8%.
    % change in max lifespan
    Maximum lifespan is up to 8% higher.
    % change in avg or median lifespan
    Mean lifespan is up to 16% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference

      Homologs in other organisms

      No homologs found

      External links

      FlyBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (41387)
      Homologues
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      UniProt
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      Internet
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