Drosophila melanogasterGenAge entry for Mnt (Drosophila melanogaster)

Gene information (ID: 439)

Symbol
Mnt
Aliases
bHLHe43; CG13316; CG2856; dMad; Dmel\CG13316; DmMnt; dmn
Name
CG13316-PC, isoform C
Organism
Drosophila melanogaster (AnAge)
Known functions and activities
Homolog of the mammalian Mnt and Mad family of transcriptional repressors

Potential relevance to longevity and/or ageing

Observations
Mnt overexpression in flies lowers climbing defects and increases both median and maximum lifespan.
% change in max lifespan
Maximum lifespan is aproximately 20% higher.
% change in avg or median lifespan
Median lifespan is aproximately 35% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    A dMnt null allele results in flies with larger cells, increased weight, and decreased lifespan.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Knockout
    Longevity Category
    Pro-Longevity
    Primary reference

      Homologs in other organisms

      No homologs found

      External links

      FlyBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (31331)
      Homologues
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      UniProt
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      Internet
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