Mus musculusGenAge entry for Mgat5 (Mus musculus)

Gene information (ID: 436)

Symbol
Mgat5
Aliases
AI480971; GlcNAc-TV; 4930471A21Rik; 5330407H02Rik
Name
mannoside acetylglucosaminyltransferase 5
Organism
Mus musculus (AnAge)
Known functions and activities
Mannoside acetylglucosaminyltransferase 5

Potential relevance to longevity and/or ageing

Observations
Although grossly normal at birth, knockout mice display multiple deficiencies with age including hypersensitivity to autoimmune disease, higher oxidative metabolism, resistance to weight-gain, and signs of early ageing such as osteoporosis, decreased muscle mass, and depletion of adult stem cells. Interestingly, Mgat5-/-Pten+/- and Mgat5+/-Pten+/- mutant mice showed a small but significant increase in lifespan when compared to Pten+/- mice, accompanied by an apparent delay in the inevitable development of cancer in Pten+/- mice.
Lifespan Effect
Decrease
Genetic Manipulation
Knockout
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    mgat5
    Homo sapiens
    MGAT5
    Rattus norvegicus
    Mgat5

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (107895)
    Homologues
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    UniProt
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    Internet
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