Mus musculusGenAge entry for Mcm2 (Mus musculus)

Gene information (ID: 427)

Symbol
Mcm2
Aliases
BM28; CDCL1; Mcmd2; AA959861; AW476101; mKIAA0030
Name
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
Organism
Mus musculus (AnAge)
Known functions and activities
Chromatin modification

Potential relevance to longevity and/or ageing

Observations
Conditional knockouts with reduced expression develop normally but lifespan is greatly reduced with most animals living 10-12 weeks accompanied by deficiencies in the proliferative cell compartments of several tissues and increased cancer incidence.
Lifespan Effect
Decrease
Genetic Manipulation
Conditional knockout
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as mcm-2

    Homologs in other organisms

    Caenorhabditis elegans
    mcm-2
    Danio rerio
    mcm2
    Drosophila melanogaster
    Mcm2
    Homo sapiens
    MCM2
    Rattus norvegicus
    Mcm2
    Saccharomyces cerevisiae
    MCM2
    Schizosaccharomyces pombe
    mcm2

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (17216)
    Homologues
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    UniProt
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    Internet
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