- Symbol
- Mcm2
- Aliases
- BM28; CDCL1; Mcmd2; AA959861; AW476101; mKIAA0030
- Name
- minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- Chromatin modification
- Observations
- Conditional knockouts with reduced expression develop normally but lifespan is greatly reduced with most animals living 10-12 weeks accompanied by deficiencies in the proliferative cell compartments of several tissues and increased cancer incidence.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Conditional knockout
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as mcm-2
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as MCM2
- Caenorhabditis elegans
- mcm-2
- Danio rerio
- mcm2
- Drosophila melanogaster
- Mcm2
- Homo sapiens
- MCM2
- Rattus norvegicus
- Mcm2
- Saccharomyces cerevisiae
- MCM2
- Schizosaccharomyces pombe
- mcm2
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (17216)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Mcm2 (Mus musculus)