Drosophila melanogasterGenAge entry for MTF-1 (Drosophila melanogaster)

Gene information (ID: 870)

Symbol
MTF-1
Aliases
anon-WO0118547.411; CG3743; Dmel\CG3743; dMTF-1; mtf-1
Name
Metal response element-binding Transcription Factor-1
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Both mean and maximal lifespan of male flies was extended upon MTF-1 overexpression in either the peripheral nervous system or motorneurons
% change in max lifespan
Maximum male lifespan is up to 40% higher.
% change in avg or median lifespan
Average male lifespan is up to 40% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Homo sapiens
    GLIS1
    Rattus norvegicus
    Glis1

    External links

    FlyBase
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    Entrez Gene
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    Homologues
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    UniProt
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    Internet
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