Saccharomyces cerevisiaeGenAge entry for MPT5 (Saccharomyces cerevisiae)

Gene information (ID: 441)

Symbol
MPT5
Aliases
HTR1; PUF5; UTH4
Name
Mpt5p
Organism
Saccharomyces cerevisiae (AnAge)
Known functions and activities
Binds to mRNAs encoding chromatin modifiers and spindle pole body components

Potential relevance to longevity and/or ageing

Observations
Overexpression extended lifespan by about 25%.
% change in avg or median lifespan
Lifespan is about 25% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Overexpression of MPT5 extends replicative life span by about 20%
    % change in avg or median lifespan
    Replicative lifespan is 20% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      Average chronological lifespan decreased by 50%. Rescued to the wt level by PKC1 overexpression
      % change in avg or median lifespan
      Replicative lifespan is 50% lower.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      Deletion
      Longevity Category
      Necessary for fitness
      Primary reference

        Homologs in other organisms

        Caenorhabditis elegans
        fbf-2
        Schizosaccharomyces pombe
        SPAC6G9.14

        External links

        Saccharomyces Genome Database
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (852697)
        Homologues
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        UniProt
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        Internet
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