Drosophila melanogasterGenAge entry for Lnk (Drosophila melanogaster)

Gene information (ID: 864)

Symbol
Lnk
Aliases
CG; 17367; CG17367; CG5908; Dmel\CG17367; dSH2B; lnk
Name
CG17367 gene product from transcript CG17367-RC
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Disruption of dSH2B (lnk) decreases insulin-like signaling and somatic growth in flies, and dSH2B deficiency increased hemolymph carbohydrate levels, whole-body lipid levels, lifespan (in both males and females), and resistance to starvation and oxidative stress. Systemic overexpression of dSH2B results in the opposite phenotypes.
% change in max lifespan
Maximum lifespan is 14% higher in males and 15% higher in females.
% change in avg or median lifespan
Median lifespan is 14% higher in males and 33% higher in females.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Loss of Lnk function results in increased median and maximum lifespan, reduces female fecundity and improves survival under conditions of oxidative stress and starvation. Heterozygosity did not result in any significant differences in lifespan in either males or females. Additionally, lifespan extension observed in one of the female homozygous mutant was fully rescued by the introduction of a Lnk genomic rescue construct.
    % change in avg or median lifespan
    Median female lifespan is up to 14% higher; Median male lifespan is up to 17.5% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Mutations
    Longevity Category
    Anti-Longevity
    Primary reference

      Homologs in other organisms

      Danio rerio
      sh2b1
      Homo sapiens
      SH2B2
      Mus musculus
      Sh2b2
      Rattus norvegicus
      Sh2b2

      External links

      FlyBase
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      Entrez Gene
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      Homologues
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      UniProt
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      Internet
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