Mus musculusGenAge entry for Kl (Mus musculus)

Gene information (ID: 395)

Symbol
Kl
Aliases
alpha-kl
Name
Klotho
Organism
Mus musculus (AnAge)
Known functions and activities
Calcium metabolism

Potential relevance to longevity and/or ageing

Observations
Disruption results in infertility and signs of premature ageing such as a short lifespan, arteriosclerosis, skin atrophy, osteoporosis, and emphysema.
Lifespan Effect
Decrease
Genetic Manipulation
Knockout
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Overexpression of Klotho in mice extends life span
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      Many advanced ageing-like KL -/- phenotypes are restored to normal whenever Klotho expression is induced. Conversely, decreasing Klotho expression in these rescued KL -/- mice induced several ageing-like KL -/- phenotypes.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      Conditional knockout
      Longevity Category
      Pro-Longevity
      Primary reference

        In other databases

        GenAge human genes
        • A homolog of this gene for Homo sapiens is present as KL
        LongevityMap
        • A homolog of this gene for Homo sapiens is present as KL
        CellAge
        • A homolog of this gene for Homo sapiens is present as KL

        Homologs in other organisms

        Danio rerio
        kl
        Homo sapiens
        KL
        Rattus norvegicus
        Kl

        External links

        Mouse Genome Informatics
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (16591)
        Homologues
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        UniProt
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        Internet
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