Mus musculusGenAge entry for Kcna3 (Mus musculus)

Gene information (ID: 822)

Symbol
Kcna3
Aliases
Mk-3; Kv1.3; Kca1-3
Name
Potassium voltage-gated channel, shaker-related subfamily, member 3
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Kv1.3-null mice weigh less than their WT counterparts, have modified ingestive behaviors, are resistant to fat deposition following a moderately high-fat dietary regime and have improved longevity and fecundity. Moreover, gene-targeted deletion of Kv1.3 in MC4R-null mice (36% shorter lifespan compared to WT) returned the lifespan of these mice to approximately WT levels.
% change in avg or median lifespan
Average lifespan is 22% higher.
Lifespan Effect
Increase
Genetic Manipulation
Deletion
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as KCNA3

    Homologs in other organisms

    Danio rerio
    LOC100150068
    Homo sapiens
    KCNA3
    Rattus norvegicus
    Kcna3

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (16491)
    Homologues
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    UniProt
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    Internet
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