Mus musculusGenAge entry for Insr (Mus musculus)

Gene information (ID: 373)

Symbol
Insr
Aliases
IR; IR-A; IR-B; CD220; 4932439J01Rik; D630014A15Rik
Name
Insulin receptor
Organism
Mus musculus (AnAge)
Known functions and activities
Signal tranduction of insulin

Potential relevance to longevity and/or ageing

Observations
Deletion in adipose tissue increased lifespan.
Lifespan Effect
Increase
Genetic Manipulation
Deletion
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Homologous murine model was created by replacing Pro-1195 of insulin receptors with Leu. Homozygous mice died in the neonatal stage from diabetic ketoacidosis, whereas heterozygous mice showed the suppressed kinase activity of the insulin receptor but grew normally without spontaneously developing diabetes during adulthood. Under 80% oxygen, mutant female mice survived 33.3% longer than wild-type female mice, whereas mutant male mice survived 18.2% longer than wild-type male mice.
    % change in avg or median lifespan
    Female average lifespan is 33.3% higher; Male average lifespan is 18.2% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Mutations
    Longevity Category
    Anti-Longevity
    Primary reference

      In other databases

      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as INSR
      LongevityMap
      • A homolog of this gene for Homo sapiens is present as INSR

      Homologs in other organisms

      Danio rerio
      insrb
      Homo sapiens
      INSR
      Rattus norvegicus
      Insr

      External links

      Mouse Genome Informatics
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (16337)
      Homologues
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      UniProt
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      Internet
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