Drosophila melanogasterGenAge entry for Indy (Drosophila melanogaster)

Gene information (ID: 366)

Symbol
Indy
Aliases
anon-EST:fe3A7; anon-WO0172774.70; BEST:LP01220; CG39
Name
I'm not dead yet protein
Organism
Drosophila melanogaster (AnAge)
Known functions and activities
Sodium-dependent citrate transporter

Potential relevance to longevity and/or ageing

Observations
No effects of Indy on lifespan were observed after controlling for genetic background via backcrossing and Wolbachia infection.
Lifespan Effect
Noeffect
Longevity Category
Not Recorded
Primary reference
    Observations
    Flies heterozygotic for a disruption have extended mean (87-92%) lifespan and maximum lifespan (45%). Homozygotes for the disruption show only a 10-20% increase in mean lifespan.
    % change in max lifespan
    Maximum lifespan is 45% higher.
    % change in avg or median lifespan
    Average lifespan is 87-92% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Knockout
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      Reduction of Indy leads to a significant lifespan extension (26% male and 11% female).
      % change in avg or median lifespan
      Average female lifespan is 11% higher; Average male lifespan is 26% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      Mutations
      Longevity Category
      Anti-Longevity
      Primary reference

        In other databases

        GenDR gene manipulations
        • This gene is present as Indy

        Homologs in other organisms

        Schizosaccharomyces pombe
        SPBC3B8.04c

        External links

        FlyBase
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (40049)
        Homologues
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        UniProt
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        Internet
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