Drosophila melanogasterGenAge entry for InR (Drosophila melanogaster)

Gene information (ID: 368)

Symbol
InR
Aliases
18402; CG18402; DIHR; DILR; dinr; dInr; dInR; dINR; DInr; D
Name
Insulin-like 1 receptor
Organism
Drosophila melanogaster (AnAge)
Known functions and activities
InR regulates cell growth and proliferation through the dP13K/dAkt pathway

Potential relevance to longevity and/or ageing

Observations
Mutations result in dwarf females with extended lifespan of up to 85% and dwarf males with reduced late age-specific mortality.
% change in avg or median lifespan
Average female lifespan is up to 85% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as daf-2
    GenDR gene manipulations
    • This gene is present as InR
    • A homolog of this gene for Caenorhabditis elegans is present as daf-2

    Homologs in other organisms

    Caenorhabditis elegans
    daf-2
    Danio rerio
    igf1rb
    Homo sapiens
    INSRR
    Mus musculus
    Insrr
    Rattus norvegicus
    Insrr

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (42549)
    Homologues
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    UniProt
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    Internet
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