Mus musculusGenAge entry for Ikbkb (Mus musculus)

Gene information (ID: 1811)

Symbol
Ikbkb
Aliases
IKK2; IKK-2; IKK[b]; IKKbeta; AI132552; IKK-beta
Name
inhibitor of kappaB kinase beta
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Brain-specific knockout mice live 23% longer. Moreover, viral activation in the hypothalamus activated NFkB and reduced lifespan.
% change in avg or median lifespan
Average lifespan is 23% higher.
Lifespan Effect
Increase
Genetic Manipulation
Knockout
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as IKBKB

    Homologs in other organisms

    Danio rerio
    ikbkb
    Homo sapiens
    IKBKB
    Rattus norvegicus
    Ikbkb

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (16150)
    Homologues
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    UniProt
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    Internet
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