Drosophila melanogasterGenAge entry for Hsp70Ba (Drosophila melanogaster)

Gene information (ID: 1013)

Symbol
Hsp70Ba
Aliases
CG31449; dhsp70; dHsp70; Dm-hsp70; Dmel\CG31449; Hsp; 70
Name
Heat shock 70kDa protein 1A
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
hsp70 and hsp22 RNA levels were higher in long-lived than in short-lived fly lines. The HDAC inhibitor TSA (causing a higher expression of hsp22 and hsp70) strikingly influenced the lifespan in both long and short-lived lines, with variable degrees (up to 25%).
% change in max lifespan
Maximum lifespan is up to 16% higher.
% change in avg or median lifespan
Average lifespan is up to 25% higher.
Lifespan Effect
Increase
Genetic Manipulation
Epigenetic modification
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Reduced mean and maximal lifespan (up to 30%) when overexpressed.
    % change in max lifespan
    Maximum lifespan is 30% lower.
    % change in avg or median lifespan
    Average lifespan is 30% lower.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Overexpression
    Longevity Category
    Anti-Longevity
    Primary reference

      Homologs in other organisms

      No homologs found

      External links

      FlyBase
      Search
      Ensembl
      Search
      Entrez Gene
      View on Entrez Gene database (44921)
      Homologues
      Search HomoloGene
      UniProt
      Search
      Internet
      Search Google or Search Google Scholar