Drosophila melanogasterGenAge entry for Hsp22 (Drosophila melanogaster)

Gene information (ID: 854)

Symbol
Hsp22
Aliases
22; anon-WO0118547.50; anon-WO0140519.138; CG32041; CG
Name
Heat shock protein 22
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Overexpression increases mean lifespan by more than 30% and increases the premortality phase.
% change in avg or median lifespan
Average lifespan is more than 30% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    TSA (Histone deacetylase (HDAC) inhibitor Trichostatin A (TSA)) could extend the lifespan of Drosophila melanogaster by promoting the hsp22 gene transcription, and affecting the chromatin morphology at the locus of hsp22 gene along the polytene chromosome.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Epigenetic modification
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      Mean lifespan was reduced up to 21% upon doxycycline-regulated overexpression of Hsp22, particularly at higher culture temperatures.
      % change in avg or median lifespan
      Average lifespan is up to 21% lower.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      Overexpression
      Longevity Category
      Anti-Longevity
      Primary reference
        Observations
        Reduced mean and maximal lifespan when overexpressed
        Lifespan Effect
        Decrease
        Genetic Manipulation
        Overexpression
        Longevity Category
        Anti-Longevity
        Primary reference

          Homologs in other organisms

          Caenorhabditis elegans
          CELE_F08H9.4
          Danio rerio
          hspb8

          External links

          FlyBase
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          Entrez Gene
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          Homologues
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          UniProt
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          Internet
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