Mus musculusGenAge entry for Hnrnpd (Mus musculus)

Gene information (ID: 819)

Symbol
Hnrnpd
Aliases
Auf1; Hnrpd
Name
heterogeneous nuclear ribonucleoprotein D
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
AUF1-deficient mice undergo striking telomere erosion, markedly increased DNA damage responses at telomere ends, pronounced cellular senescence, and rapid premature aging that increases with successive generations, which can be rescued in AUF1 knockout mice and their cultured cells by resupplying AUF1 expression. Auf1 -/- mice in all genetic backgrounds displayed classic hallmarks of accelerated aging, including kyphosis (hunchback), reduced subcutaneous body fat, and atrophy of the reproductive organs in most animals by 12 months of age
Lifespan Effect
Decrease
Genetic Manipulation
Knockout
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    hnrnpd
    Homo sapiens
    HNRNPD
    Rattus norvegicus
    Hnrnpd

    External links

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