Saccharomyces cerevisiaeGenAge entry for HRD1 (Saccharomyces cerevisiae)

Gene information (ID: 1313)

Symbol
HRD1
Aliases
DER3
Name
HMG-coA Reductase Degradation
Organism
Saccharomyces cerevisiae (AnAge)

Potential relevance to longevity and/or ageing

Observations
Deletion of hrd1, a target of the unfolded protein response signaling, increases replicative lifespan.
% change in avg or median lifespan
Mean lifespan is 18% higher.
Lifespan Effect
Increase
Genetic Manipulation
Deletion
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Mean chronological lifespan strongly decreased in the a strain
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Deletion
    Longevity Category
    Necessary for fitness
    Primary reference

      Homologs in other organisms

      Drosophila melanogaster
      sip3
      Schizosaccharomyces pombe
      hrd1

      External links

      Saccharomyces Genome Database
      Search
      Ensembl
      Search
      Entrez Gene
      View on Entrez Gene database (854149)
      Homologues
      Search HomoloGene
      UniProt
      Search
      Internet
      Search Google or Search Google Scholar