Saccharomyces cerevisiaeGenAge entry for HCM1 (Saccharomyces cerevisiae)

Gene information (ID: 1870)

Symbol
HCM1
Name
Hcm1p
Organism
Saccharomyces cerevisiae (AnAge)

Potential relevance to longevity and/or ageing

Observations
Strong overexpression of HCM1 results in a 30% increase in yeast replicative lifespan when comparing to wild-type, while weaker overexpression has no effect on life span. Complementary, HCM1 deletion results in a 30% decrease in yeast replicative lifespan. Manipulation of HCM1 levels does not extend yeast chronological life span.
% change in avg or median lifespan
Mean replicative lifespan is 30% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    si:dkey-11f5.5
    Mus musculus
    Foxo6
    Schizosaccharomyces pombe
    mei4

    External links

    Saccharomyces Genome Database
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (850429)
    Homologues
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    UniProt
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    Internet
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